Bioinformatics Mcqs

Page No. 79

Conservation of gene order due to operon structure is _______ so interactions of proteins specific to eukaryotes cannot be detected by method of Conservation of gene order.


anot applicable to archea genomes


bnot applicable to prokaryote genomes


c applicable to eukaryote genomes


dnot applicable to eukaryote genomes



In a quantitative assessment of this method (Conservation of gene order) using the genome of the parasitic organism Mycoplasma genitalium as a benchmark.


a True


bFalse


ceither true and false


dnone of the mentioned


View Answer True

Members of a stable complex are often co-regulated and thus will be detected by the method of Conservation of gene order.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

When comparing pairs of genes or sets of genes in different genomes for this purpose, it is not mandatory for the genes to be orthologs.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer False

Genes that are consistently part of the same operon across different, distantly related genomes are likely to be part of the same protein complex or functional process across all species.


aTrue


bFalse


ceihter true and false


dnone of the mentioned


View Answer True

Interactions between proteins can be predicted computationally by looking for sets of genes that occur as a _______


asingle gene in at least one genome


bmultiple genes in at least one genome


cmultiple genes in various genomes


d single gene in various genomes



Experimentation is most desirable over computational methods by every means.


aTrue


bFalse


ceihter ture and false


dnone of the mentioned


View Answer False

Which of the following is untrue about Shotgun Sequencing?


aWhen DNA fragments derived from different chromosomal regions have repeats of the same sequence, they will appear to overlap


bWhen DNA fragments derived from different chromosomal regions have repeats of the same sequence, they will appear to scrutinize


c In a new whole shotgun approach, Celera Genomics is sequencing both ends of DNA fragments of short (2 kb), medium (10 kb), and long (BAC or >100 kb) lengths


dA large number of reads are then assembled by computer



An alternative method is to sequence all the subclones, produce a computer database of the sequences, and then have the computer assemble the sequences from the overlaps that are found.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

Once the correct map has been obtained, unique overlapping clones are chosen for sequencing.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

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