Bioinformatics Mcqs

Page No. 92

Which of the given statements is incorrect about Clusters of orthologous groups?


aUsing the protein from one of the organisms to search the proteome of the other for high-scoring matches should identify the ortholog as the highest- scoring match, or best hit


b When entire proteomes of the two organisms are available, orthologs may be identified


ca pair of orthologous genes in two organisms share so much sequence similarity that they may be assumed to have arisen from a common ancestor gene


deach of the orthologs belongs to a family composed of paralogous sequences but irrelevant or not related to each other



Which of the given statements is incorrect about Grouping Sequences?


aThe problem of deciding which sequences to include in the same group or cluster and which to separate into different groups or clusters is a recurring one


bDivergence is necessary, but the sequences chosen should be clearly related based on inspection of each pair-wise alignment and a statistical analysis


cThe conservative approach is to group distinct sequences


dThe adventurous approach is to choose a set of marginally alignable sequences to pursue the difficult task of making a multiple sequence alignment and then to make profile models that may recognize divergence but will also give false predictions



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