Bioinformatics Mcqs

Page No. 91

Which of the given statements is incorrect about All-against-all Self-comparison?


aA comparison of each protein in the proteome with all other proteins distinguishes unique proteins from proteins that have arisen from gene duplication, and also reveals the number of protein families but the domain content of these proteins cannot be known

✓


bIn all-against-all proteome comparison, each protein is used as a query in a similarity search against the remaining proteome

✖


cIn all-against-all proteome comparison, the similar sequences are ranked by the quality and length of the alignments found

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dIn all-against-all proteome comparison, The search is conducted with each alignment score receiving a statistical evaluation (P or E value)

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View Answer A comparison of each protein in the proteome with all other proteins distinguishes unique proteins from proteins that have arisen from gene duplication, and also reveals the number of protein families but the domain content of these proteins cannot be known

Which of the given statements is incorrect?


aProteins may be clustered into families on the basis of either sequence or structural similarity

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bProteins often comprise separate domains

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cThe number of protein sequences that are available is insufficient to determine that domain shuffling occurs in evolution

✓


dProteins are modular

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View Answer The number of protein sequences that are available is insufficient to determine that domain shuffling occurs in evolution

Which of the following information Sequence comparisons do not provide?


aGene relationships

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bFunction history

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cEvolutionary history

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dGene locations

✓


View Answer Gene locations

Comparative genomics includes a comparison of gene number, gene content, and gene location in both prokaryotic and eukaryotic groups of organisms.


aTrue

✓


bFalse

✖


ceither true and false

✖


dnone of the mentioned

✖


View Answer True

Annotation is based on finding significant alignment to sequences of known function in database similarity searches.


aTrue

✓


bFalse

✖


ceither true and false

✖


dnone of the mentioned

✖


View Answer True

Which of the given statements is incorrect about Horizontal Gene Transfer?


aThe genomes of most organisms are derived by vertical transmission, the inheritance of chromosomes from parents to offspring from one generation to the next

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b It is the acquisition of genetic material from a different organism

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cThe transferred material becomes a temporary addition to the recipient genome

✓


dAn extreme example is the proposed endosymbiont origin of mitochondria in eukaryotic cells and chloroplasts in plants

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View Answer The transferred material becomes a temporary addition to the recipient genome

Which of the given statements is incorrect about Ancient Conserved Regions?


aThe method involves database similarity searches of the SwissProt database with human, worm, yeast, or E. coli genes and identification of matches with sequences from a different phylum than the query sequence

✖


bAn analysis of ACRs that predate the radiation of the major animal phyla some 580–540 million years ago suggested that 50–60% of coding sequences are ACRs

✓


cThese ACRs may represent proteins present at the time of the prokaryotic–eukaryotic divergence

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dPhylogenetically diverse groups of organisms have been analyzed for the presence of conserved proteins and protein domains that have been conserved over long periods of evolutionary time, called ancient conserved regions or ACRs

✖


View Answer An analysis of ACRs that predate the radiation of the major animal phyla some 580–540 million years ago suggested that 50–60% of coding sequences are ACRs

Which of the given statements is incorrect about Family and Domain Analysis?


aGene identification of predicted proteins in the genome is designed to discover the metabolic features of an organism

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bIn a particular organism or group of organisms, one particular domain can be expanded to perform a particular function

✓


cComparison of the domain content of an entire proteome with that of another proteome cannot help in revealing the biological roles of diverse domains in different organisms

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dDifferent proteins are mosaics of domains that occur in different combinations in a given protein

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View Answer In a particular organism or group of organisms, one particular domain can be expanded to perform a particular function

Which of the given statements is incorrect about Searching for orthologs to a protein family in an EST database?


aSearches of EST databases for matches to a query sequence routinely produce minimal amounts of output that must be searched manually for significant hits

✓


bESTs with a high percent identity with the query sequence, a long alignment with the query sequence, and a very low E value of the alignment score represent groups of paralogous and orthologous genes

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cTo identify orthologs as the most closely related sequence, ESTs were aligned using the amino acid alignment as a guide

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dTo identify orthologs as the most closely related sequence, a phylogenetic tree was produced by the maximum likelihood method

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View Answer Searches of EST databases for matches to a query sequence routinely produce minimal amounts of output that must be searched manually for significant hits

Which of the given statements is incorrect about the Comparison of proteomes to EST databases of an organism?


aESTs are single DNA sequence reads that contain a small fraction of incorrect base assessments, insertions, and deletions

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bMany sequences arise from near the 5’ end of the mRNA, although every effort is usually made to read as far 3’ as possible into the upstream portion of the cDNA

✓


cEST libraries are useful for preliminary identification of genes by database similarity searches

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dAn EST database of an organism can be analyzed for the presence of gene families, orthologs, and paralogs

✖


View Answer Many sequences arise from near the 5’ end of the mRNA, although every effort is usually made to read as far 3’ as possible into the upstream portion of the cDNA

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