Bioinformatics Mcqs

Page No. 1

In the zinc finger, which residues in this sequence motif form ligands to a zinc ion?


aCysteine and histidine

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bCysteine and histidine

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cHistidine and proline

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dHistidine and arginine

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Which of the following is not the function of Short Linear Motifs?


a Irreversible cleavage of the peptide at the SLiM

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bReversible cleavage of the peptide at the SLiM

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cMoiety addition at targeted sites on SLiM

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d Structural modifications of the peptide backbone

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The protein structural motif domain- helix loop helix are contained by all of the following except ________


aScleraxis

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bNeurogenins

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cTranscription Factor 4

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dTranscription Factor 4

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Which of the following wrongly describes protein domains?


aThey are made up of one secondary structure

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bDefined as independently foldable units

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cThey are stable structures as compared to motifs

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dThey are separated by linker regions

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Motifs that can form α/β horseshoes conformation are rich with which protein residue?


aProline

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bArginine

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cValine

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dLeucine

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View Answer Leucine

Which of the following least describes Long Loop β-hairpins?


aThey are Often referred to as a ‘random coil’ conformation

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bGenerally they are referred to as the β-meander supersecondary structure

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c Loop looks similar to the Greek Letter Ω

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dWide-range of conformations witWide-range of conformations with very specific sequence preferencesh very specific sequence preferences

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Which of the common structural motifs are described wrongly?


aβ-hairpin – adjacent antiparallel strands

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bGreek key – 4 adjacent antiparallel strand

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cβ-α-β – 2 parallel strands connected by helix

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dβ-α-β – 2 antiparallel strands connected by helixβ-α-β – 2 antiparallel strands connected by helix

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Which of the following is false about the ‘loop’ structure in proteins?


aThey connect helices and sheets

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b They are more tolerant of mutations

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cThey are more flexible and can adopt multiple conformations

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dThey are never the components of active sites

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On average, what is the length of a typical domain?


aAbout 100 residues

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bAbout 300 residues

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c About 500 residues

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d About 900 residues

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View Answer About 100 residues

What is the length of a motif, in terms of amino acids residue?


a30- 60

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b10- 20

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c70- 90

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d1- 10

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View Answer 10- 20

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