Bioinformatics Mcqs

Page No. 78

In the Interaction map of domain families, the interactions of one family represent the sum of all the interactions of domains in that family.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

In protein domain family interaction map, the physical contacts of the domains in different families are represented by the lines between the nodes.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

Which of the following is untrue?


aMany entries in the Protein DataBank (PDB) are three-dimensional structures of multiple domains


b The structures in PDB provide experimental information about interactions between domains at atomic detail


cThere are comparatively few three-dimensional structures compared to the amount of data available from the lower resolution large-scale experiments


dMany entries in the Protein DataBank (PDB) are two-dimensional structures of multiple domains



Structural analyses on small sets of proteins have shown that the domains from a pair of families bind to each other with the same geometry in multi-domain proteins and in transient interactions.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

In the phylogenetic profile method for predicting protein interaction, presence or absence of orthologous genes is scored across a variety of genomes.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

In the assessment of methods to predict protein-protein interactions, one third of such pairs were found to physically interact, and an additional third to belong to the same metabolic pathway or functional process.


a True


bFalse


ceither true and false


dnone of the mentioned


View Answer True

The phylogenetic profile method relies on detection of orthologs (or homologs, in a variation of the method) in a set of genomes.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

Due to the requirement for co-regulation as well as colocalization, the method is mostly limited to certain classes of protein-protein interactions.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

Domains that are part of a multidomain protein are ______


anethier co-regulated nor colocalized


bnot co-regulated but colocalized


cco-regulated and but not colocalized


dco-regulated and colocalized



An approach for predicting ______ to look for cases across a set of genomes where _____ are part of the same gene in one genome resulted in gene fusion method.


a gene interactions, only three to four orthologs


bgene interactions, two orthologs


cprotein interactions, two or more orthologs


d protein interactions, two orthologs



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