Bioinformatics Mcqs

Page No. 76

An understanding of the importance of different factors in a particular interaction is important if confidence in the results is required. Which of the following are not those factors?


aShape


bHydrophobicity


cElectrostatics


dpH


View Answer pH

The ______ is an ongoing community-wide experiment on the comparative evaluation of protein-protein docking for structure prediction.


aChronological Assignment of Prediction of Interactions (CAPRI)


bChronological Assessment of Prediction of Interactions (CAPRI)


cCritical Assignment of Prediction of Interactions (CAPRI)


d Critical Assessment of Prediction of Interactions (CAPRI)



There was little degree of success in docking an antibody-antigen complex in the second challenge for the protein-protein docking evaluation.


a True


bFalse


ceither true and false


dnone of the mentioned


View Answer True

In case of protein-protein docking, the level of success is dependent on the system under study.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

In a similar way to structure prediction methods models can be evaluated using RMSD to measure the similarity between two molecular complexes.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

Which of the following is incorrect about Purification of protein complexes followed by mass spectrometry?


aIsolating protein complexes from cells allows identification of interactions between ensembles of proteins instead of just pairs


bSystematic purification of complexes on a large scale is done by tagging hundreds of genes with an epitope


cUnLike in the yeast-two-hybrid assay, this does not involve chimeric genes


dAffinity purification based on the epitope will then extract all the proteins attached to the bait protein from cell lysates



Which of the following is incorrect about Yeast-two-hybrid screens?


aThe yeast-two-hybrid system uses the transcription of a reporter gene driven by the Gal4 transcription factor to monitor whether or not two proteins are interacting


bThe DNA-binding domain chimeric protein will not bind upstream of the reporter gene


cIf the activation domain chimeric protein interacts with the DNA-binding domain chimeric protein, the reporter gene will be transcribed


dDisadvantages of the method are that only pairwise interactions are tested, and not interactions that can only take place when multiple proteins come together, as well as a high false positive rate



For proteins in stable complexes the average sequence identity is 46%, while for proteins in transient interactions it is 41%.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

Membership in a stable complex also differs from transient interaction in terms of evolutionary constraints upon sequence divergence.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

Correlation of gene expression for pairs of transiently interacting proteins is ______ compared to randomly chosen pairs of proteins.


anot significant


bonly marginally significant


ctotally significant


dsignificant to much extent



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