Bioinformatics Mcqs

Page No. 75

The disadvantage of Multiple conformation rigid-body method is that the active conformation may be missed as the result of a minor structural difference not considered in the ______ ligand conformations. Where, the N is the number of low-energy conformations.


aN +1


bN


cN2


dN/2


View Answer N

In Multiple conformation rigid-body method, a ligand is assumed to be able to adopt a number (N) of different _______ that are computed _____ the ligand being docked into the receptor.


alow-energy conformations, after


blow-energy conformations, prior to


chigh-energy conformations, prior to


dhigh-energy conformations, after



In case of Protein-ligand docking, ______ ligands are often _____ in adapting their shape to fit the receptor binding pocket.


asmall molecule, highly flexible


blarge molecule, highly flexible


clarge molecule, more flexible


dsmall molecule, less flexible



Typical motions of proteins will be primarily treated by a rigid body model for docking.


aTrue


b False


ceither true and false


dnone of the mentioned


View Answer False

Proteins are dynamic entities that undergo _______


aonly fluctuation of flexible loop regions about equilibrium positions when in solution


bonly limited conformational change of amino acid side-chains when in solution


cboth limited conformational change of amino acid side-chains and fluctuation of flexible loop regions about equilibrium positions when in solution


d illimitable or total conformational change of amino acid side-chains when in solution



The GRASP and VRLM have been incorporated into the GRASS server.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

The popular program RasMol can be made to view molecular properties by assigning those properties to the temperature factor column of the sdf file in question only.


aTrue


bFalse


ceither true and fasle


dnone of the mentioned


View Answer False

Visualization methods are very important in viewing molecular properties on molecules. Of particular note is the rendering of molecular surfaces according to their various properties (that can be expressed numerically).


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

In practical circumstances there exists an experimental structure of the complex.


aTrue


bFalse


ceither true and false


dnone of mentioned


View Answer True

Information about shape, hydrophobicity, electrostatics, evolutionary relationships and conformational flexibility is not always available and the search for a universally applicable scoring function as well as an adequate treatment of conformational flexibility is ongoing.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

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