Bioinformatics Mcqs

Page No. 73

Which of the following is untrue about Bayes Aligner?


aPosterior probability values, which are considered estimates of the true alignment, are calculated for each alignment


bThe method generates a single best alignment


cIt aligns two sequences using a Bayesian algorithm which is a unique sequence alignment method


dIt is a web-based footprinting program



rVISTA uses two orthologous sequences as input and first identifies all putative regulatory motifs based on TRANSFAC matches.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

Which of the following is untrue about ConSite?


a It is a web server that finds putative promoter elements


bIt includes comparing two orthologous sequences


cThe program does not accept pre-computed alignment


dThe program accepts pre-computed alignment



A caveat of phylogenetic footprinting is to extract noncoding sequences Upstream of corresponding genes and focus the comparison to this region only, which helps to prevent false positives.


a True


bFalse


ceither true and false


dnone of these


View Answer True

Which of the following is incorrect regarding Phylogenetic Footprinting–Based Method?


a It is possible to obtain promoter sequences for a particular gene through comparative analysis


bThe conservation from closely related organisms is both at the sequence level and at the level of organization of the elements


cThe conservation from closely related organisms is most at the sequence level


dIt has been observed that promoter and regulatory elements from closely related organisms such as human and mouse are highly conserved



Which of the following is untrue about Electrostatic Complementarity?


aThe electrostatic properties of biomolecules play an important role in determining interactions


bThe burial of charged residues at protein-protein/DNA interfaces is thought to be generally net destabilizing with the hydrophobic effect being the primary driving force


cCharged groups involved in the biomolecular interface are often stabilized by other polar or oppositely charged groups on the interacting molecule


dCharged groups involved in the biomolecular interface are often stabilized by similar polar or same charged groups on the interacting molecule



Oligomers are often obligate complexes meaning that the free-energy cost of dissociation is high and they exist as oligomers under physiological conditions.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

Which of the following is untrue about Hydrophobicity?


aThe hydrophobic effect plays a dominant role in the folding of proteins


bHydrophobic residues aggregate away from contact with water


cHydrophobic residues aggregate to form hydrophobic cores with more polar residues


dHydrophobic residues form the solvent accessible surface but restrict the solubility of the protein



In Property-based measures, displaying physical properties on the molecular surface of molecules can help to guide molecular docking.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

In Grid representation, the lowest score represents the best surface complementarity for a given translational scan.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer False

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