Bioinformatics Mcqs

Page No. 73

Which of the following is untrue about Bayes Aligner?


aPosterior probability values, which are considered estimates of the true alignment, are calculated for each alignment

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bThe method generates a single best alignment

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cIt aligns two sequences using a Bayesian algorithm which is a unique sequence alignment method

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dIt is a web-based footprinting program

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rVISTA uses two orthologous sequences as input and first identifies all putative regulatory motifs based on TRANSFAC matches.


aTrue

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bFalse

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ceither true and false

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dnone of these

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View Answer True

Which of the following is untrue about ConSite?


a It is a web server that finds putative promoter elements

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bIt includes comparing two orthologous sequences

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cThe program does not accept pre-computed alignment

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dThe program accepts pre-computed alignment

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A caveat of phylogenetic footprinting is to extract noncoding sequences Upstream of corresponding genes and focus the comparison to this region only, which helps to prevent false positives.


a True

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bFalse

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ceither true and false

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dnone of these

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View Answer True

Which of the following is incorrect regarding Phylogenetic Footprinting–Based Method?


a It is possible to obtain promoter sequences for a particular gene through comparative analysis

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bThe conservation from closely related organisms is both at the sequence level and at the level of organization of the elements

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cThe conservation from closely related organisms is most at the sequence level

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dIt has been observed that promoter and regulatory elements from closely related organisms such as human and mouse are highly conserved

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Which of the following is untrue about Electrostatic Complementarity?


aThe electrostatic properties of biomolecules play an important role in determining interactions

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bThe burial of charged residues at protein-protein/DNA interfaces is thought to be generally net destabilizing with the hydrophobic effect being the primary driving force

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cCharged groups involved in the biomolecular interface are often stabilized by other polar or oppositely charged groups on the interacting molecule

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dCharged groups involved in the biomolecular interface are often stabilized by similar polar or same charged groups on the interacting molecule

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Oligomers are often obligate complexes meaning that the free-energy cost of dissociation is high and they exist as oligomers under physiological conditions.


aTrue

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bFalse

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ceither true and false

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dnone of the mentioned

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View Answer True

Which of the following is untrue about Hydrophobicity?


aThe hydrophobic effect plays a dominant role in the folding of proteins

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bHydrophobic residues aggregate away from contact with water

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cHydrophobic residues aggregate to form hydrophobic cores with more polar residues

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dHydrophobic residues form the solvent accessible surface but restrict the solubility of the protein

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In Property-based measures, displaying physical properties on the molecular surface of molecules can help to guide molecular docking.


aTrue

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bFalse

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ceither true and false

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dnone of the mentioned

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View Answer True

In Grid representation, the lowest score represents the best surface complementarity for a given translational scan.


aTrue

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bFalse

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ceither true and false

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dnone of the mentioned

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View Answer False

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