Bioinformatics Mcqs

Page No. 32

Which of the following is untrue regarding Ab Initio–Based Methods?


aThis type of method predicts the secondary structure based on a single query sequence


b This type of method predicts the secondary structure based on a multiple query sequence


cIt measures the relative propensity of each amino acid belonging to a certain secondary structure element


d The propensity scores are derived from known crystal structures



The secondary structure prediction methods can be either ab initio based, which make use of single sequence information only, or homology based, which makes use of multiple sequence alignment information.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

The formation of _____ is determined by ______ interactions, whereas the formation of ____ is strongly influenced by ______ interactions.


a α-helices, long-range, α-helices, short-range


bα-helices, long-range, β-strands, short-range


c α-helices, short-range, β-strands, long-range


d β-strands, short-range, β-strands, long-range



. Scanning a sequence by hydrophobicity does not reveal transmembrane β-strands.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

Which of the following is true regarding Prediction of β-Barrel Membrane Proteins?


aFor membrane proteins with β-strands only, the β-strands forming the transmembrane segment are amphipathic in nature


b For membrane proteins with β-strands only, the β-strands forming the transmembrane segment are only hydrophilic in nature


cFor membrane proteins with β-strands only, the β-strands forming the transmembrane segment are only hydrophobic in nature


dThey contain six to nine residues



Which of the following is untrue regarding Phobius?


aIt is a web-based program designed to overcome false positives caused by the presence of signal peptides


bThe program incorporates distinct HMM models for signal peptides only


cThe program incorporates distinct HMM models for signal peptides as well as transmembrane helices


dAfter distinguishing the putative signal peptides from the rest of the query sequence, prediction is made on the remainder of the sequence



Which of the following is untrue regarding TMHMM?


a It is a web-based program based on an HMM algorithm


bIt is trained to recognize transmembrane helical patterns


cIt is not trained to recognize transmembrane helical patterns


dWhen a query sequence is scanned, the probability of having an α-helical domain is given



The presence of ______ signal peptides can significantly compromise the prediction _______ because the programs tend to confuse hydrophobic signal peptides with membrane helices.


ahydrophobic, accuracy


bhydrophobic, error


chydrophilic, accuracy


dhydrophilic, error


View Answer hydrophobic, accuracy

Predictions solely based on hydrophobicity profiles have lowest error rates.


aTrue


bFalse


ceither true and false


dnone of these


View Answer False

The early algorithms based their prediction on hydrophobicity scales.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

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