Bioinformatics Mcqs

Page No. 33

Which of the following is untrue regarding Prediction of Helical Membrane Proteins?


aFor membrane proteins consisting of transmembrane α–helices, these transmembrane helices are predominantly hydrophobic with a specific distribution of positively charged residues


bThe α-helices generally run perpendicular to the membrane plane


cThe α-helices generally run parallel to the membrane plane


dThe α-helices have an average length between seventeen and twenty-five residues



The structures of this group of proteins, however, are comparatively a lot difficult to resolve either by x-ray crystallography or nuclear magnetic resonance (NMR) spectroscopy.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

Which of the following is untrue regarding the transmembrane proteins?


aConstitute up to 30% of all cellular proteins


bThey are responsible for performing a wide variety of important functions in a cell, such as signal transduction, cross-membrane transport, and energy conversion


c The membrane proteins are also of tremendous biomedical importance


dThey are not drug targets or receptors



Jpred combines the analysis results from six prediction algorithms, including PHD, PREDATOR, DSC, NNSSP, Jnet, and ZPred.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

Prof is not similar to PHD.


a True


b False


ceither true and false


dnone of these


View Answer False

Which of the following is untrue regarding PSIPRED?


aIt is a web-based program that predicts protein secondary structures


b It uses a combination of evolutionary information and neural networks


c It uses a combination of evolutionary information only


d The multiple sequence alignment is derived from a PSI-BLAST database search



Leucine zipper domains are a special type of coiled coils found in transcription regulatory proteins which contain two anti parallel α-helices held together by hydrophobic interactions of leucine residues.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

In Multicoil, The scoring matrix is constructed based on a database of known three-stranded coiled coils only.


aTrue


bFalse


ceither true and false


dnone of these


View Answer False

Which of the following is untrue regarding Coils?


a It is a web-based program that detects coiled coil regions in proteins


bIt scans a window of fourteen, twenty-one, or twenty-eight residues


c It scans a window of It scans a window of fourteen or twenty-one residues onlyfourteen or twenty-one residues only


d It compares the sequence to a probability matrix compiled from known parallel two-stranded coiled coils



Which of the following is true regarding Coiled coil?


aThey have an integral repeat of twenty residues


b They have an integral repeat of seven residues


cThey have an integral repeat of thirty residues


dThe sequence periodicity doesn’t contribute in designing algorithms to predict the structural domain.



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