Bioinformatics Mcqs

Page No. 34

Coiled coils are super helical structures involving two to more interacting α-helices from the same or different proteins.


aTrue

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bFalse

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ceither true and false

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dnone of these

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View Answer True

In Rosetta, The segments with assigned _______ structures are subsequently assembled into a ______ dimensional configuration.


a primary, three

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b secondary, three

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c secondary, two

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d primary, three

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View Answer secondary, three

Rosetta is a web server that predicts protein three-dimensional conformations using the ab initio method.


aTrue

✓


bFalse

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ceither true and false

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dnone of these

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View Answer True

Searching for a fold with the absolute minimum energy may not be valid in reality.


aTrue

✓


bFalse

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ceither true and false

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dnone of these

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View Answer True

The prediction programs are thus designed using the energy minimization principle.


aTrue

✓


b False

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ceither true and false

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dnone of these

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View Answer True

Which of the following is untrue about Ab initio prediction?


aThe limited knowledge of protein folding forms the basis of ab initio prediction

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bThe ab initio prediction method attempts to produce all-atom protein models based on sequence information alone without the aid of known protein structures

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cThe ab initio prediction method attempts to produce all-atom protein models based on sequence information alone with some aid of known protein structures

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dThe perceived advantage of this method is that predictions are not restricted by known folds and that novel protein folds can be identified

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Energy minimization has to be used with caution because excessive energy minimization often moves residues away from their correct positions.


aTrue

✓


bFalse

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ceither true and false

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dnone of these

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View Answer True

In the step of Model Refinement Using Energy Function, the structural irregularities can be corrected by applying the energy minimization procedure on the entire model, which moves the atoms in such a way that the overall conformation has the lowest energy potential.


a True

✓


bFalse

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ceither true and false

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done of these

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View Answer True

. In Side Chain Refinement step, A side chain can be built by searching every possible conformation at every torsion angle of the side chain to select the one that has the lowest interaction energy with neighboring atoms.


aTrue

✓


b False

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ceither true and false

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dnone of these

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View Answer True

Which of the following is untrue about specialized programs for loop modeling?


aPETRA is a web server that models loops using the database approach

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bFREAD is a web server that models loops using the database approach

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cCODA is a web server that uses a consensus method based on the prediction results from FREAD and PETRA

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dFor loops of three to eight residues, CODA uses consensus conformation of both methods

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