Bioinformatics Mcqs

Page No. 34

Coiled coils are super helical structures involving two to more interacting α-helices from the same or different proteins.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

In Rosetta, The segments with assigned _______ structures are subsequently assembled into a ______ dimensional configuration.


a primary, three


b secondary, three


c secondary, two


d primary, three


View Answer secondary, three

Rosetta is a web server that predicts protein three-dimensional conformations using the ab initio method.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

Searching for a fold with the absolute minimum energy may not be valid in reality.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

The prediction programs are thus designed using the energy minimization principle.


aTrue


b False


ceither true and false


dnone of these


View Answer True

Which of the following is untrue about Ab initio prediction?


aThe limited knowledge of protein folding forms the basis of ab initio prediction


bThe ab initio prediction method attempts to produce all-atom protein models based on sequence information alone without the aid of known protein structures


cThe ab initio prediction method attempts to produce all-atom protein models based on sequence information alone with some aid of known protein structures


dThe perceived advantage of this method is that predictions are not restricted by known folds and that novel protein folds can be identified



Energy minimization has to be used with caution because excessive energy minimization often moves residues away from their correct positions.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

In the step of Model Refinement Using Energy Function, the structural irregularities can be corrected by applying the energy minimization procedure on the entire model, which moves the atoms in such a way that the overall conformation has the lowest energy potential.


a True


bFalse


ceither true and false


done of these


View Answer True

. In Side Chain Refinement step, A side chain can be built by searching every possible conformation at every torsion angle of the side chain to select the one that has the lowest interaction energy with neighboring atoms.


aTrue


b False


ceither true and false


dnone of these


View Answer True

Which of the following is untrue about specialized programs for loop modeling?


aPETRA is a web server that models loops using the database approach


bFREAD is a web server that models loops using the database approach


cCODA is a web server that uses a consensus method based on the prediction results from FREAD and PETRA


dFor loops of three to eight residues, CODA uses consensus conformation of both methods



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