Bioinformatics Mcqs

Page No. 36

Which of the following is untrue about profile method?


aA profile is constructed for a group of related protein structures

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bThe propensity of amino acids in not in picture of this method

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cStatistical information from these aligned residues is then used to construct a profile

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dThe structural profile is generated by the superimposition of the structures to expose corresponding residues

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The next step in the pairwise energy based method is to build a crude model for the target sequence by replacing aligned residues in the template structure with the corresponding residues in the query.


aTrue

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bFalse

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ceither true and false

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dnone of these

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View Answer True

In the pairwise energy based method, a protein sequence is searched for in a structural fold database to find the best matching structural fold using ______ criteria.


a sequence-based

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b structure-based

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cenergy-based

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dresidue-based'

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View Answer energy-based

The algorithms used here can be classified into two categories, pairwise energy based and profile based.


aTrue

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bFalse

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ceither true and false

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dnone of these

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View Answer True

Threading or structural fold recognition predicts the structural fold of an unknown protein sequence by fitting the sequence into a structural database and selecting the best-fitting fold.


aTrue

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b False

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ceither true and false

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dnone of these

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View Answer True

There are a large number of protein folds available, compared to millions of protein sequences.


aTrue

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b False

✓


ceither true and false

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dnone of these

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View Answer False

The __________ refers to two single-stranded regions on opposite strands connecting two adjacent base-paired segments.


ahairpin loop

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binterior loop

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c pseudoknot loop

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d helical junctions

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View Answer interior loop

The ______ refers to a structure with two ends of a single-stranded region (loop) connecting a base-paired region (stem).


ahelical junctions

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bhairpin loop

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cbulge loop

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dinterior loop

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View Answer hairpin loop

Four main subtypes of secondary structures can be identified. They are hairpin loops, bulge loops, interior loops, and multi-branch loops.


aTrue

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b False

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ceither true and false

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dnone of these

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View Answer True

In addition to the canonical base pairing, there often exists non-canonical base pairing such as _________ and ________ base paring.


aG, U

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bG, C

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cU, C

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dA, C

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View Answer G, U

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