Bioinformatics Mcqs

Page No. 36

Which of the following is untrue about profile method?


aA profile is constructed for a group of related protein structures


bThe propensity of amino acids in not in picture of this method


cStatistical information from these aligned residues is then used to construct a profile


dThe structural profile is generated by the superimposition of the structures to expose corresponding residues



The next step in the pairwise energy based method is to build a crude model for the target sequence by replacing aligned residues in the template structure with the corresponding residues in the query.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

In the pairwise energy based method, a protein sequence is searched for in a structural fold database to find the best matching structural fold using ______ criteria.


a sequence-based


b structure-based


cenergy-based


dresidue-based'


View Answer energy-based

The algorithms used here can be classified into two categories, pairwise energy based and profile based.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

Threading or structural fold recognition predicts the structural fold of an unknown protein sequence by fitting the sequence into a structural database and selecting the best-fitting fold.


aTrue


b False


ceither true and false


dnone of these


View Answer True

There are a large number of protein folds available, compared to millions of protein sequences.


aTrue


b False


ceither true and false


dnone of these


View Answer False

The __________ refers to two single-stranded regions on opposite strands connecting two adjacent base-paired segments.


ahairpin loop


binterior loop


c pseudoknot loop


d helical junctions


View Answer interior loop

The ______ refers to a structure with two ends of a single-stranded region (loop) connecting a base-paired region (stem).


ahelical junctions


bhairpin loop


cbulge loop


dinterior loop


View Answer hairpin loop

Four main subtypes of secondary structures can be identified. They are hairpin loops, bulge loops, interior loops, and multi-branch loops.


aTrue


b False


ceither true and false


dnone of these


View Answer True

In addition to the canonical base pairing, there often exists non-canonical base pairing such as _________ and ________ base paring.


aG, U


bG, C


cU, C


dA, C


View Answer G, U

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