Bioinformatics Mcqs

Page No. 38

The attractive interactions lead to _________ energy.


a increased


bhigher


clower


dno change in


View Answer lower

The energy necessary to form individual base pairs is not quite affected by adjacent base pairs.


aTrue


b False


ceither true and false


dnone of these


View Answer False

In ab initio methods, free energy can be calculated based on parameters empirically derived for small molecules.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

In ab initio approach, generally, when a base pairing is formed, the energy of the molecule is _________ because of attractive interactions between the two strands.


alowered


bincreased


cmultiplied


dkept stable


View Answer lowered

Ab initio approach makes structural predictions based on ______


a single RNA sequence


bcomparing RNA sequences


cevolutionary basis


dpure phylogenetics



At present, there are essentially two types of method of RNA structure prediction. One is the minimum free energy approach and the Second one is a comparative approach


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

Which of the following about the RNAFold is incorrect?


a It extends the sequence alignment to the vicinity of the optimal diagonals to calculate thermodynamic stability of alternative structures


b It incorporates a partition function


c It doesn’t necessarily use a partition function


d It aims to select a number of statistically most probable structures in one of its steps



Like Mfold, RNAfold only examines the energy terms of the optimal alignment in a dot plot.


aTrue


bFalse


ceither true and false


dnone of these


View Answer False

Which of the following is correct about MFOLD?


a It uses the dynamic programming only


bIt uses the thermodynamic calculations only


cIt uses the both dynamic programming and thermodynamic calculations as well


dIt doesn’t take into account the themoststablility of the secondary structures



The problem of dynamic programming to select one single structure can be complemented by adding a probability distribution function, known as the _________ which calculates a mathematical distribution of probable base pairs in thermodynamic equilibrium.


apartition function


bdivision function


c increment function


dfold function


View Answer partition function

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