Bioinformatics Mcqs

Page No. 31

The second step in structure classification is to separate structurally distinct domains within a structure.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

The first step in structure classification is to remove redundancy from databases.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

The classification results from both systems, SCOP and CATH are quite dissimilar.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer False

Which of the following is untrue regarding PHD?


aIt stands for Profile network from Heidelberg


b It is a web-based program that combines neural network only


cIt first performs a BLASTP of the query sequence against a non redundant protein sequence database


d In initial steps it finds a set of homologous sequences, which are aligned with the MAXHOM program (a weighted dynamic programming algorithm performing global alignment)



Which of the following is untrue regarding Prediction with Neural Networks?


aThe third-generation prediction algorithms extensively apply sophisticated neural networks


b It is used to analyze substitution patterns in multiple sequence alignments


cIt is not a machine learning process


dIt requires a structure of multiple layers of interconnected variables or nodes



Because residues in the same aligned position are assumed to have the same secondary structure, any inconsistencies or errors in prediction of individual sequences can be corrected using a majority rule.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

Which of the following is untrue regarding Homology-Based Methods?


aThe third generation of algorithms was developed in the late 1990s


bThey were developed by making use of evolutionary information


cThis type of method uses the ab initio secondary structure prediction of individual sequences onl


dThis type of method combines the ab initio secondary structure prediction of individual sequences and alignment information from multiple homologous sequences (>35% identity)



Which of the following is untrue regarding Chou–Fasman and GOR methods?


aBoth are the first-generation methods


bThey are developed in the 1970s,


cThey suffer from the fact that the prediction rules are somewhat arbitrary


dThey are based on single sequence statistics with clear relation to known protein-folding theories



The GOR method is based on the “propensity” of each residue to be in one of the two conformational states, helix (H), strand(E).


aTrue


b False


ceither true and false


dnone of these


View Answer False

The Chou–Fasman algorithm determines the propensity or intrinsic tendency of each residue to be in the helix, strand, and β-turn conformation using observed frequencies found in protein crystal structures.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

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