Bioinformatics Mcqs

Page No. 30

Which of the following is incorrect about intermolecular approach?


aThis procedure starts with identifying equivalent residues or atoms


bAfter residue–residue correspondence is established, one of the structures is moved laterally and vertically toward the other structure to allow the two structures to be in the same location


che structures are rotated relative to each other around the three-dimensional axes


dThe rotation doesn’t depend on the intermolecular distance



The intermolecular approach is normally applied to relatively _____ structures.


adistinctive


bdissimilar


csimilar


ddifferent


View Answer similar

Which of the following is incorrect about protein structure comparison?


aThe comparative approach is important in finding remote protein homologs


bProtein structures have a much higher degree of conservation than the sequences


cProtein structures have a much lesser degree of conservation than the sequences


dProteins can share common structures even without sequence similarity



CATH is a combination of manual curation and automated procedure, which makes the process less subjective.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

SCOP is _______ based on manual comparison of structures by human experts with no quantitative criteria to group proteins.


aentirely


balmost entirely


cnot


dpartially


View Answer almost entirely

Which of the following is untrue about SCOP and CATH?


aThe definition for class in CATH is quite dissimilar to that in SCOP


bThe definition for class in CATH is based on secondary structure content


cArchitecture is a unique level in CATH, intermediate between fold and class


dThe definition for class in CATH is similar to that in SCOP



In CATH, Structural domain separation is carried by ___________


amanual comparison only


bcomputer programs only


chuman expertise only


da combined effort of a human expert and computer programs



Members within the ____ fold ______ have evolutionary relationships.


asame, always


bsame, do not always


cone, always


ddifferent, do not


View Answer same, do not always

Which of the following is untrue about SCOP?


aIt is a database for comparing and classifying protein structures


bIt is constructed almost entirely based on manual examination of protein structures


cThe proteins are grouped into hierarchies of classes, folds, superfamilies, and families


dThe SCOP families consist of proteins having low sequence identity (>30%)



The last step in structure classification involves grouping proteins/domains of similar structures.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

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