Bioinformatics Mcqs

Page No. 17

Which of the following is untrue about Protein substitution matrices?


aThey are significantly more complex than DNA scoring matrices


b They have the N x N matrices of the amino acids


c Protein substitution matrices have quite important role in evolutionary studies


d They are significantly quite less complex than DNA scoring matrices



The substitution matrices are rarely used in this type of matching.


aTrue


bFalse


ceither true and false


dnone of these


View Answer False

The alignment score is the sum of substitution scores and gap penalties in this type of algorithm.


aTrue


b False


ceither true and false


dnone of these


View Answer True

The global sequence alignment is suitable when the two sequences are of dissimilar length, with a negligible degree of similarity throughout.


aTrue


bFalse


ceither true and false


dnone of these


View Answer False

A dotplot is a visual and qualitative technique whereas the sequence alignment is an exact and quantitative measure of similarity of alignments.


aTrue


b False


ceither true and false


dnone of these


View Answer True

Which of the following is not the objective to perform sequence comparison?


aTo observe patterns of conservation


b To find the common motifs present in both sequences


cTo study the physical properties of molecules


dTo study evolutionary relationships



The resulting tree is then used to guide the alignment of the most closely related sequences and groups of sequences. The resulting alignment is a global alignment produced by the Needleman-Wunsch algorithm.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

Which of the following is untrue about PILEUP program?


aIt is the MSA program that is a part of the Genetics Computer Group package of sequence analysis programs


bIt is owned since 1997 by Oxford Communications and is widely used due to the popularity and availability of this package


c It uses a method for MSA that is polar opposite to CLUSTALW


dThe sequences are aligned pair-wise using the Needleman- Wunsch dynamic programming algorithm



. Like other alignment programs, CLUSTAL uses a null score for opening a gap in a sequence alignment and a penalty for extending the gap by one residue.


aTrue


b False


ceither true and false


dnone of these


View Answer False

The scoring of gaps in a MSA (Multiple Sequence Alignment) has to be performed in a different manner from scoring gaps in a pair-wise alignment.


aTrue


bFalse


ceither true and fasle


dnone of these


View Answer True

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