Bioinformatics Mcqs

Page No. 19

The first step in Genetic Algorithm is arranging the sequences to be aligned in rows.


aTrue


b False


ceither true and false


dnone of these


View Answer True

An approach for obtaining a higher-scoring MSA (Multiple Sequence Alignment) by rearranging an existing alignment uses a probability approach called simulated annealing


a True


b False


ceither true and false


dnone of these


View Answer True

The Genetic Algorithm method has been recently adapted for MSA(Multiple Sequence Alignment) by Corpet (1998).


aTrue


bFalse


ceither true and false


dnone of these


View Answer False

In the program DIALIGN, pairs of sequences are aligned to locate aligned regions that do not include gaps, much like continuous diagonals in a dot matrix plot.


aTrue


b False


ceither true and false


dnone of these


View Answer True

Which of the following is incorrect regarding PRRP?


aThe program PRRP uses iterative methods to produce an alignment


b An initial pair-wise alignment is made to predict a tree


c Only one cycle is performed


dThe whole process is repeated until there is no further increase in the alignment score



Iterative methods include repeatedly realigning subgroups of the sequences and then by aligning these subgroups into a local alignment of all of the sequences.


aTrue


b False


ceither true and false


dnone of these


View Answer False

Although MOTIF program is used successfully for making the BLOCKS database, it is limited in the pattern sizes that can be found.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

The pattern searching method type of analysis was performed on groups of related proteins, and the amino acid patterns that were located may be found in the Prosite catalog.


a True


bFalse


ceither true and false


dnone of these


View Answer True

Which of the following is not true regarding the BLOCKS?


aBlocks of width 10–55 are extracted from a protein MSA


b The protein MSA is up to 400 sequences


c The program doesn’t accept manually reformatted MSAs


dThe program accepts FASTA format



In the method of extraction of blocks from a global or local MSA, a global MSA of related protein sequences usually includes regions that have been aligned without gaps in any of the sequences.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

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