Bioinformatics Mcqs

Page No. 18

. The initial alignments used to produce the guide tree may be obtained by various methods. Which of the following is not one of them?


aFast k-tuple

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bpattern-finding approach similar

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cFASTA

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dFaster, full dynamic programming method

✓



Which of the following is untrue about CLUSTAL program?


aCLUSTAL performs a global-multiple sequence alignment by a different method than MSA (Multiple Sequence Alignment)

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b The initial heuristic alignment obtained by MSA is calculated in a different way

✓


cThe initial step includes performing pair-wise alignments of all of the sequences

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dThe intermediate step includes use the alignment scores to produce a phylogenetic tree

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The CLUSTALX provides a graphic interface.


aTrue

✓


bFalse

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ceither true and false

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dnone of these

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View Answer True

CLUSTALW is a more recent version of CLUSTAL with the W standing for ________


aweakening

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b winding

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c weighting

✓


dwiping

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View Answer weighting

Progenitor sequences represented by the ______ branches of the tree are derived by alignment of the _______ sequences.


aouter, outermost

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binner, outermost

✓


c inner, innermost

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douter, innermost

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View Answer inner, outermost

Progressive alignment methods use the dynamic programming method to build an MSA starting with the most related sequences and then progressively adding less related sequences or groups of sequences to the initial alignment.


aTrue

✓


bFalse

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ceither true and false

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dnone of these

✖


View Answer True

Which of the following is not true about iterative methods?


aGenetic Algorithm is method used for under this

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bHidden Markov Models are used for Multiple Sequence Alignment

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cThe objective is to improve the overall alignment score

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dMultAlin recalculates global scores

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The HMM is a statistical model that considers few combinations of matches and gaps to generate an alignment of a set of sequence


a True

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bFalse

✓


ceither true and false

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dnone of these

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View Answer False

In Genetic Algorithm, in the mutation process _______


a sequence is changed

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bgaps are not inserted

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csequence is not changed

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dgaps are not rearranged

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The second step in the Genetic Algorithm comprises of scoring of the 100 initial MSAs by the sum of pairs method.


a True

✓


bFalse

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ceither true and false

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dnone of these

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View Answer True

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