Bioinformatics Mcqs

Page No. 18

. The initial alignments used to produce the guide tree may be obtained by various methods. Which of the following is not one of them?


aFast k-tuple


bpattern-finding approach similar


cFASTA


dFaster, full dynamic programming method



Which of the following is untrue about CLUSTAL program?


aCLUSTAL performs a global-multiple sequence alignment by a different method than MSA (Multiple Sequence Alignment)


b The initial heuristic alignment obtained by MSA is calculated in a different way


cThe initial step includes performing pair-wise alignments of all of the sequences


dThe intermediate step includes use the alignment scores to produce a phylogenetic tree



The CLUSTALX provides a graphic interface.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

CLUSTALW is a more recent version of CLUSTAL with the W standing for ________


aweakening


b winding


c weighting


dwiping


View Answer weighting

Progenitor sequences represented by the ______ branches of the tree are derived by alignment of the _______ sequences.


aouter, outermost


binner, outermost


c inner, innermost


douter, innermost


View Answer inner, outermost

Progressive alignment methods use the dynamic programming method to build an MSA starting with the most related sequences and then progressively adding less related sequences or groups of sequences to the initial alignment.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

Which of the following is not true about iterative methods?


aGenetic Algorithm is method used for under this


bHidden Markov Models are used for Multiple Sequence Alignment


cThe objective is to improve the overall alignment score


dMultAlin recalculates global scores



The HMM is a statistical model that considers few combinations of matches and gaps to generate an alignment of a set of sequence


a True


bFalse


ceither true and false


dnone of these


View Answer False

In Genetic Algorithm, in the mutation process _______


a sequence is changed


bgaps are not inserted


csequence is not changed


dgaps are not rearranged



The second step in the Genetic Algorithm comprises of scoring of the 100 initial MSAs by the sum of pairs method.


a True


bFalse


ceither true and false


dnone of these


View Answer True

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