Bioinformatics Mcqs

Page No. 14

If the score is located in the extreme margin of the distribution, that means that the alignment between the two sequences is ______ due to random chance and is thus considered ______


a unlikely, significant


b unlikely, insignificant


c unlikely, insignificant


dvery likely, significant



What is used to generate parameters for the extreme distribution?


a The pool of alignment scores from the shuffled sequences


bA single score of a shuffled sequence


cThe pool of alignment scores from the unshuffled sequences


dThe basic optimal score computed at the beginning of the test



In the statistical test, randomization process in which one of the two given sequences is randomly shuffled.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

Which of the following is a part of the statistical test of sequences?


aAn optimal alignment between two chosen sequences is obtained at the end


bUnrelated sequences of the same length are then generated through a randomization process


cUnrelated sequences of the different length are then generated through a randomization process


dRelated sequences of the same length are then generated through a randomization process



Many studies have demonstrated that the distribution of similarity scores assumes a peculiar shape that resembles a highly skewed normal distribution with a long tail on one side. The distribution matches the _______


aGumble elective value distribution


bGumble extreme void distribution


cGumble end value distribution


d Gumble extreme value distribution



By calculating alignment scores of a large number of ______ sequence pairs, a distribution model of the ______ sequence scores can be derived.


arelated, randomized


bunrelated, randomized


c unrelated, unrandomized


drelated, unrandomized


View Answer unrelated, randomized

The truly statistically significant sequence alignment will be able to provide evidence of homology between the sequences involved.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

Which of the following is untrue about DCA?


aIt stands for Divide-and-Conquer Alignment


bIt works by breaking each of the sequences into two smaller sections


cThe breaking points during the process are determined based on regional similarity of the sequences


d) If the sections are not short enough, further divisions are restricted as well



As the amount of computational time and memory space required increases exponentially with the number of sequences, it makes the multidimensional search matrix method computationally prohibitive to use for a large data set.


a True


b False


ceither true and false


dnone of these


View Answer True

In a multidimensional search matrix, for aligning N sequences, an (N+2)-dimensional matrix is needed to be filled with alignment scores.


aTrue


b False


ceither true and false


dnone of these


View Answer False

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