Bioinformatics Mcqs

Page No. 12

Which of the following is incorrect regarding sequence homology?


a Two sequences can homologous relationship even if have do not have common origin


b It is an important concept in sequence analysis


cWhen two sequences are descended from a common evolutionary origin, they are said to have a homologous relationship


d) When two sequences are descended from a common evolutionary origin, they are said to share homology



Sometimes, it is also possible that two sequences have derived from a common ancestor, but may have diverged to such an extent that the common ancestral relationships are not recognizable at the sequence level.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

If the two sequences share significant similarity, it is extremely ______ that the extensive similarity between the two sequences has been acquired randomly, meaning that the two sequences must have derived from a common evolutionary origin.


aunlikely


bpossible


clikely


drelevant


View Answer unlikely

The degree of sequence variation in the alignment reveals evolutionary relatedness of different sequences, whereas the conservation between sequences reflects the changes that have occurred during evolution in the form of substitutions, insertions, and deletions


aTrue


bFalse


ceither true and false


dnone of these


View Answer False

The presence of evolutionary traces is because some of the residues that perform key functional and structural roles tend to be preserved by natural selection; other residues that may be less crucial for structure and function tend to mutate more frequently.


a True


bFalse


ceither true and false


done of these


View Answer True

Which of the following is incorrect about evolution?


aThe macromolecules can be considered molecular fossils that encode the history of millions of years of evolution


bThe building blocks of these biological macromolecules, nucleotide bases, and amino acids form linear sequences that determine the primary structure of the molecules


cDNA and proteins are products of evolution


dThe molecular sequences barely undergo changes



Which of the following is incorrect regarding pair wise sequence alignment?


aThe most fundamental process in this type of comparison is sequence alignment


b It is an important first step toward structural and functional analysis of newly determined sequences


cThis is the process by which sequences are compared by searching for common character patterns and establishing residue-residue correspondence among related sequences


d It is the process of aligning multiple sequences



Which of the following is untrue about dot plot method and its applications?


aThis method gives a direct visual statement of the relationship between two sequences


bOne of its advantages is the identification of sequence repeat regions based on the presence of parallel diagonals of the same size vertically or horizontally in the matrix


cIt is not useful in identifying chromosomal repeats


dThe method can be used in identifying nucleic acid secondary structures through detecting self-complementarity of a sequence



Self complementarity of DNA sequences cannot be identified using a dot plot.


aTrue


bFalse


ceither true and false


dnone of these


View Answer False

A sequence can be aligned with itself to identify internal repeat elements.


a True


b False


ceither true and false


dnone of these


View Answer True

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