Bioinformatics Mcqs

Page No. 10

If the random sequences were prepared in a way that maintained the local base composition by producing them from overlapping fragments of sequence, the distribution of scores has a _______ standard deviation that is closer to the distribution of the natural sequences.


alowest


bhigher


c lower


dmoderate


View Answer lower

_______ analyzed the distribution of scores among 100 vertebrate nucleic acid sequences and compared these scores with randomized sequences prepared in different ways.


aLipman, in 1984


bBatalov, in 1964


c Waterman, in 1987


d Lipman, in 1967


View Answer Lipman, in 1984

Who suggested that the global alignment scores between unrelated protein sequences followed the extreme value distribution, similar to local alignment scores? And when?


a Abagyan and Batalov, in 1981


b Chvátal and Lipman, in 1984


cAbagyan and Batalov, in 1997


dChvátal and Sankoff, in 1995



Which of the following are not related to Needleman-Wunsch alignment algorithm?


aGlobal alignment programs use this algorithm


bThe output is a positive number


cSmall changes in the scoring system can produce a different alignment


dChanges in the scoring system can produce the same alignment



When random or unrelated sequences are compared using a global alignment method, they can have ____________ reflecting the tendency of the global algorithm to match as many characters as possible.


avery low scores


bvery high scores


cmoderate scores


dlow scores


View Answer very high scores

The statistical analysis of alignment scores is much better understood for ________ than for _______


aglobal alignments, local alignments


b local alignments, global alignments


c global alignments, any other alignment method


dNeedleman-Wunsch alignment, Smith-Waterman alignment



On analysis of the alignment scores of random sequences will reveal that the scores follow a different distribution than the normal distribution called the _________


aGumbel equal value distribution


bGumbel extreme value distribution


cGumbel end value distribution


d Gumbel distribution



Unlike the commonly used methods for aligning a pair of sequences, the Bayesian method _______ using a particular scoring matrix or designated gap penalties.


adoes not depend on


bdepends on


cis based on


dinvolves


View Answer does not depend on

Zhu (1998) have devised a computer program called the Bayes block aligner which in effect slides ____ sequences along each other to find the ______ ungapped regions or blocks.


atwo, least scoring


btwo, highest scoring


cmultiple, highest scoring


dmultiple, least scoring


View Answer two, highest scoring

Which of the following feature of Bayesian methods is the disadvantage of it?


aA length and distance that gives the highest overall probability may be determined


bThey are used to calculate evolutionary distance


cComputationally Bayesian methods are better


d A specific mutational model is required



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