Bioinformatics Mcqs

Page No. 8

Which of the following is true for EMBOSS Dottup?


aAllows you to specify threshold

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b Doesn’t allow you to specify threshold

✓


c Doesn’t allow you to specify window size

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dIf all cells in the window are identity, it colors in some specific cells in the window

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Who were the inventors of this method?


aSmith-Waterman

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b Margaret Preston

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cGibbs and McIntyre

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dNeedleman-Wunsch

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View Answer Gibbs and McIntyre

When was this method, first described?


a1959

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b1966

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c1970

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d1982

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View Answer 1970

For significantly aligning sequences what is the resulting structure on the plot?


aIntercrossing lines

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bCrosses everywhere

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c Vertical lines

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dA diagonal and lines parallel to diagonal

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For palindromic sequences, what is the structure of the dot plot?


a2 intersecting diagonal lines at the midpoint

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b One diagonal

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c Two parallel diagonals

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d No diagonal

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The softwares for dot plot analysis perform several tasks. Which one of them is not performed by them?


aGap open penalty

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bGap extend penalty

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cExpectation threshold

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dChange or mutate residues

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Which of the following is not a software for dot plot analysis?


aSIMMI

✓


b DOTLET

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cDOTMATCHER

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dLALIGN

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View Answer SIMMI

Which of the following is untrue regarding dynamic programming algorithm?


aThe method compares every pair of characters in the two sequences and generates an alignment

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bThe output alignment will include matched and mismatched characters and gaps in the two sequences that are positioned so that the number of matches between identical or related characters is the maximum possible

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cThe dynamic programming algorithm provides a reliable computational method for aligning DNA and protein sequences

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dThis doesn’t allow making evolutionary predictions on the basis of sequence alignments

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A feature of the dynamic programming algorithm is that the alignments obtained depend on the choice of a scoring system for comparing character pairs and penalty scores for gaps.


aTrue

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b False

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ceither true and false

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dnone of these

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View Answer True

Dayhoff PAM matrices, are based on an evolutionary model of protein change, whereas, BLOSUM matrices, are designed to identify members of the same family.


aTrue

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b False

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ceither true and false

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dnone of these

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View Answer True

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