Bioinformatics Mcqs

Page No. 8

Which of the following is true for EMBOSS Dottup?


aAllows you to specify threshold


b Doesn’t allow you to specify threshold


c Doesn’t allow you to specify window size


dIf all cells in the window are identity, it colors in some specific cells in the window



Who were the inventors of this method?


aSmith-Waterman


b Margaret Preston


cGibbs and McIntyre


dNeedleman-Wunsch


View Answer Gibbs and McIntyre

When was this method, first described?


a1959


b1966


c1970


d1982


View Answer 1970

For significantly aligning sequences what is the resulting structure on the plot?


aIntercrossing lines


bCrosses everywhere


c Vertical lines


dA diagonal and lines parallel to diagonal



For palindromic sequences, what is the structure of the dot plot?


a2 intersecting diagonal lines at the midpoint


b One diagonal


c Two parallel diagonals


d No diagonal



The softwares for dot plot analysis perform several tasks. Which one of them is not performed by them?


aGap open penalty


bGap extend penalty


cExpectation threshold


dChange or mutate residues



Which of the following is not a software for dot plot analysis?


aSIMMI


b DOTLET


cDOTMATCHER


dLALIGN


View Answer SIMMI

Which of the following is untrue regarding dynamic programming algorithm?


aThe method compares every pair of characters in the two sequences and generates an alignment


bThe output alignment will include matched and mismatched characters and gaps in the two sequences that are positioned so that the number of matches between identical or related characters is the maximum possible


cThe dynamic programming algorithm provides a reliable computational method for aligning DNA and protein sequences


dThis doesn’t allow making evolutionary predictions on the basis of sequence alignments



A feature of the dynamic programming algorithm is that the alignments obtained depend on the choice of a scoring system for comparing character pairs and penalty scores for gaps.


aTrue


b False


ceither true and false


dnone of these


View Answer True

Dayhoff PAM matrices, are based on an evolutionary model of protein change, whereas, BLOSUM matrices, are designed to identify members of the same family.


aTrue


b False


ceither true and false


dnone of these


View Answer True

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