Bioinformatics Mcqs

Page No. 13

If the selected window size is too long, sensitivity of the alignment is lost.


a True


bFalse


ceither true and false


dnone of these


View Answer True

A problem exists when comparing _____ sequences using the dot matrix method, namely, the _______


asmall, amplification


blarge, amplification


c small, high noise level


dlarge, high noise level



When the two sequences have substantial regions of similarity, many dots line up to form contiguous _______ lines.


acrossings on


bhorizontal


cdiagonal


dvertical


View Answer diagonal

In a dot matrix, two sequences to be compared are written in the _____________


a horizontal and vertical axes


b2 parallel horizontal axes


c2 parallel vertical axes


d horizontal axis (one preceding another)



Alignment algorithms, both global and local, are fundamentally similar and only differ in the optimization strategy used in aligning similar residues.


a True


b False


ceither true and false


dnone of these


View Answer True

In local alignment, the two sequences to be aligned cannot be of unequal lengths.


aTrue


bFalse


ceither true and false


dnone of these


View Answer False

The overall goal of pair wise sequence alignment is to find the best pairing of two sequences, such that there is maximum correspondence among residues.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

The major disadvantage of the PRSS program is that it doesn’t allow partial shuffling.


aTrue


bFalse


ceither true and false


dnone of these


View Answer False

Which of the following is untrue about the PRSS program?


aIt stands for Probability of Random Shuffles


b It is a web-based program that can be used to evaluate the statistical significance of DNA or protein sequence alignment


c It first aligns two sequences using the Needleman-Wunsch algorithm and calculates the score


dIt holds one sequence in its original form and randomizes the order of residues in the other sequence.



It is not known whether the Gumble distribution applies equally well to gapped alignments.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

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