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Bioinformatics Mcqs


In the zinc finger, which residues in this sequence motif form ligands to a zinc ion?


aCysteine and histidine


bCysteine and histidine


cHistidine and proline


dHistidine and arginine



Which of the following is not the function of Short Linear Motifs?


a Irreversible cleavage of the peptide at the SLiM


bReversible cleavage of the peptide at the SLiM


cMoiety addition at targeted sites on SLiM


d Structural modifications of the peptide backbone



The protein structural motif domain- helix loop helix are contained by all of the following except ________


aScleraxis


bNeurogenins


cTranscription Factor 4


dTranscription Factor 4



Which of the following wrongly describes protein domains?


aThey are made up of one secondary structure


bDefined as independently foldable units


cThey are stable structures as compared to motifs


dThey are separated by linker regions



Motifs that can form α/β horseshoes conformation are rich with which protein residue?


aProline


bArginine


cValine


dLeucine


View Answer Leucine

Which of the following least describes Long Loop β-hairpins?


aThey are Often referred to as a ‘random coil’ conformation


bGenerally they are referred to as the β-meander supersecondary structure


c Loop looks similar to the Greek Letter Ω


dWide-range of conformations witWide-range of conformations with very specific sequence preferencesh very specific sequence preferences



Which of the common structural motifs are described wrongly?


aβ-hairpin – adjacent antiparallel strands


bGreek key – 4 adjacent antiparallel strand


cβ-α-β – 2 parallel strands connected by helix


dβ-α-β – 2 antiparallel strands connected by helixβ-α-β – 2 antiparallel strands connected by helix



Which of the following is false about the ‘loop’ structure in proteins?


aThey connect helices and sheets


b They are more tolerant of mutations


cThey are more flexible and can adopt multiple conformations


dThey are never the components of active sites



On average, what is the length of a typical domain?


aAbout 100 residues


bAbout 300 residues


c About 500 residues


d About 900 residues


View Answer About 100 residues

What is the length of a motif, in terms of amino acids residue?


a30- 60


b10- 20


c70- 90


d1- 10


View Answer 10- 20

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