Bioinformatics Mcqs

Page No. 51

To generate EST data, clones in the cDNA library are randomly selected for sequencing from either end of the inserts.


aTrue

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bFalse

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ceither true and false

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dnone of these

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View Answer True

Which of the following is untrue regarding expressed sequence tags (ESTs)?


aOne of the high throughput approaches to genome-wide profiling of gene expression is sequencing ESTs

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bThey are short sequences obtained from cDNA clones

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cThey serve as short identifiers of full-length genes

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dThey are typically in the range of 800 to 900 nucleotides in length

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TIGR TM4 is a suite of multiplatform programs for analyzing microarray data.


aTrue

✓


bFalse

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ceither ture and false

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dnone of these

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View Answer True

Which of the following is incorrect about Self-Organizing Maps?


a Clustering by SOMs is in principle similar to the k-means method

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b It doesn’t involve neural networks

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cThe data points are initially assigned to the nodes at random

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dIt starts by defining a number of nodes

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Which of the following is incorrect about k-Means Clustering?


a k-means clustering produces a dendrogram

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bIt classifies data through a single step partition

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c It is a divisive approach

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dIn this method, data are partitioned into k-clusters, which are prespecified at the outset

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Which of the following is incorrect about Hierarchical Clustering?


aThe tree-branching pattern illustrates a higher degree of relationship between related gene groups

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b It is not similar to the distance phylogenetic tree-building method

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cIt produces a treelike structure that represents a hierarchy or relative relatedness of data groups

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dIn the tree leaves, similar gene expression profiles are placed more closely together than dissimilar gene expression profiles

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A supervised analysis refers to classification of data into a set of predefined categories. For example, depending on the purpose of the experiment, the data can be classified into predefined ‘diseased’ or ‘normal’ categories


aTrue

✓


bFalse

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ceither true and false

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dnone of these

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View Answer True

Which of the following is incorrect about Classification of microarray data?


aFor microarray data, clustering analysis identifies coexpressed and coregulated genes

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bFor microarray data, clustering analysis identifies coexpressed but not coregulated genes

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cFor microarray data, clustering analysis identifies and coregulated but not coexpressed genes

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dGenes within a category have more similarity in expression than genes from different categories.

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In the analysis of microarray data–If replicated datasets are available, rigorous statistical tests such as t-test and analysis of variance (ANOVA) can be performed to test the null hypothesis that a given data point is not significantly different from the mean of the data distribution.


aTrue

✓


b False

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ceither true and false

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dnone of these

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View Answer True

Which of the following is incorrect about Data Collection?


aThe two-color microarray uses multiple dyes at times

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bThe most common type of microarray protocol is the two-color microarray

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cThe cDNAs are obtained by extracting total RNA or mRNA from tissues or cells and incorporating fluorescent dyes in the DNA strands during the cDNA biosynthesis

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dThe expression of genes is measured via the signals from cDNAs hybridizing with the specific oligonucleotide probes on the microarray

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