Bioinformatics Mcqs

Page No. 51

To generate EST data, clones in the cDNA library are randomly selected for sequencing from either end of the inserts.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

Which of the following is untrue regarding expressed sequence tags (ESTs)?


aOne of the high throughput approaches to genome-wide profiling of gene expression is sequencing ESTs


bThey are short sequences obtained from cDNA clones


cThey serve as short identifiers of full-length genes


dThey are typically in the range of 800 to 900 nucleotides in length



TIGR TM4 is a suite of multiplatform programs for analyzing microarray data.


aTrue


bFalse


ceither ture and false


dnone of these


View Answer True

Which of the following is incorrect about Self-Organizing Maps?


a Clustering by SOMs is in principle similar to the k-means method


b It doesn’t involve neural networks


cThe data points are initially assigned to the nodes at random


dIt starts by defining a number of nodes



Which of the following is incorrect about k-Means Clustering?


a k-means clustering produces a dendrogram


bIt classifies data through a single step partition


c It is a divisive approach


dIn this method, data are partitioned into k-clusters, which are prespecified at the outset



Which of the following is incorrect about Hierarchical Clustering?


aThe tree-branching pattern illustrates a higher degree of relationship between related gene groups


b It is not similar to the distance phylogenetic tree-building method


cIt produces a treelike structure that represents a hierarchy or relative relatedness of data groups


dIn the tree leaves, similar gene expression profiles are placed more closely together than dissimilar gene expression profiles



A supervised analysis refers to classification of data into a set of predefined categories. For example, depending on the purpose of the experiment, the data can be classified into predefined ‘diseased’ or ‘normal’ categories


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

Which of the following is incorrect about Classification of microarray data?


aFor microarray data, clustering analysis identifies coexpressed and coregulated genes


bFor microarray data, clustering analysis identifies coexpressed but not coregulated genes


cFor microarray data, clustering analysis identifies and coregulated but not coexpressed genes


dGenes within a category have more similarity in expression than genes from different categories.



In the analysis of microarray data–If replicated datasets are available, rigorous statistical tests such as t-test and analysis of variance (ANOVA) can be performed to test the null hypothesis that a given data point is not significantly different from the mean of the data distribution.


aTrue


b False


ceither true and false


dnone of these


View Answer True

Which of the following is incorrect about Data Collection?


aThe two-color microarray uses multiple dyes at times


bThe most common type of microarray protocol is the two-color microarray


cThe cDNAs are obtained by extracting total RNA or mRNA from tissues or cells and incorporating fluorescent dyes in the DNA strands during the cDNA biosynthesis


dThe expression of genes is measured via the signals from cDNAs hybridizing with the specific oligonucleotide probes on the microarray



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