Bioinformatics Mcqs

Page No. 69

The drawback of Homology-based approach is its reliance on the presence of homologs in databases.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

Which of the following is untrue about Homology-Based Programs?


aThey are based on the fact that exon structures and exon sequences of related species are less conserved


bThis approach assumes that the database sequences are correct


cIt is a reasonable assumption in light of the fact that many homologous sequences to be compared with are derived from cDNA or expressed sequence tags (ESTs) of the same species


d Potential coding frames in a query sequence are translated and used to align with closest protein homologs found in databases



Which of the following wrong about HMM GENE?


aIt is also an HMM-based web program


bIt uses a criterion called the conditional maximum likelihood to discriminate coding from non-coding feature


cHMM prediction is unbiased toward the locked region


dIf a sequence already has a sub-region identified as coding region, which may be based on similarity with cDNAs or proteins in a database, these regions are locked as coding regions



GENSCAN is awebbased program that makes predictions based on fifth-order


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

Which of the following is untrue about FGENES?


a It stands for FindGenes


bIt is a web-based program that uses LDA


cIt is used to determine whether a signal is an exon


dIt does not make a use of HMMs



The TATA box is often used as an indicator of the presence of a promoter.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

Eukaryotic RNA polymerase II does not directly bind to the promoter, but relies on a dozen or more transcription factors to recognize and bind to the promoter in a specific order before its own binding around the promoter.


aTrue


bFalse


ceither true and false


dnone of the mentioned


View Answer True

In eukaryotes, genes often form an operon with a shared promoter.


aTrue


bFalse


ceither ture and false


dnone of the mentioned


View Answer True

In eukaryotes, gene expression is not regulated by a protein complex formed between transcription factors and RNA polymerase.


aTrue


b False


ceither ture and false


dnone of the mentioned


View Answer False

The specific DNA sequences to which the transcription factors bind are referred to as _____


areplication elements


b blocking factors


ctranscription factors


d regulatory elements



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