Bioinformatics Mcqs

Page No. 69

The drawback of Homology-based approach is its reliance on the presence of homologs in databases.


aTrue

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bFalse

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ceither true and false

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dnone of the mentioned

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View Answer True

Which of the following is untrue about Homology-Based Programs?


aThey are based on the fact that exon structures and exon sequences of related species are less conserved

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bThis approach assumes that the database sequences are correct

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cIt is a reasonable assumption in light of the fact that many homologous sequences to be compared with are derived from cDNA or expressed sequence tags (ESTs) of the same species

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d Potential coding frames in a query sequence are translated and used to align with closest protein homologs found in databases

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Which of the following wrong about HMM GENE?


aIt is also an HMM-based web program

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bIt uses a criterion called the conditional maximum likelihood to discriminate coding from non-coding feature

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cHMM prediction is unbiased toward the locked region

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dIf a sequence already has a sub-region identified as coding region, which may be based on similarity with cDNAs or proteins in a database, these regions are locked as coding regions

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GENSCAN is awebbased program that makes predictions based on fifth-order


aTrue

✓


bFalse

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ceither true and false

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dnone of the mentioned

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View Answer True

Which of the following is untrue about FGENES?


a It stands for FindGenes

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bIt is a web-based program that uses LDA

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cIt is used to determine whether a signal is an exon

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dIt does not make a use of HMMs

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The TATA box is often used as an indicator of the presence of a promoter.


aTrue

✓


bFalse

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ceither true and false

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dnone of the mentioned

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View Answer True

Eukaryotic RNA polymerase II does not directly bind to the promoter, but relies on a dozen or more transcription factors to recognize and bind to the promoter in a specific order before its own binding around the promoter.


aTrue

✓


bFalse

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ceither true and false

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dnone of the mentioned

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View Answer True

In eukaryotes, genes often form an operon with a shared promoter.


aTrue

✓


bFalse

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ceither ture and false

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dnone of the mentioned

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View Answer True

In eukaryotes, gene expression is not regulated by a protein complex formed between transcription factors and RNA polymerase.


aTrue

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b False

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ceither ture and false

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dnone of the mentioned

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View Answer False

The specific DNA sequences to which the transcription factors bind are referred to as _____


areplication elements

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b blocking factors

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ctranscription factors

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d regulatory elements

✓



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