Bioinformatics Mcqs for NTS, PPSC, FPSC TEST and others

Page No. 66

FGENESB is a web-based program that is also based on fifth-order HMMs for detecting coding regions.

a True

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b False

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ceither true and false

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dnone of these

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View Answer

True

The homology-based method makes predictions based on significant matches of the query sequence with sequences of known genes.

a True

✓

b False

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ceither true and false

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dnone of these

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View Answer

True

In the ab initio–based approaches—they rely on two major features associated with genes: one of them being gene content, which is statistical description of coding regions.

aTrue

✓

bFalse

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ceither true of false

✖

dnone of these

✖

View Answer

True

In the ab initio–based approaches—they rely on two major features associated with genes: one of them being the existence of gene signals, which include start and stop codons, intron splice signals, transcription factor binding sites, etc.

aTrue

✓

b False

✖

ceither true of false

✖

dnone of these

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View Answer

True

Which of the following is true regarding the methods of gene prediction?Which of the following is true regarding the methods of gene prediction?

aThey solely consist of a type called ab initio–based methods

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b The ab initio–based approach predicts genes based on the given sequence alone

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c The ab initio–based approach predicts genes based on the given sequence and relative homology data

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dThey solely consist of a type called homology-based approaches

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View Answer

The ab initio–based approach predicts genes based on the given sequence alone

The use of Markov models in gene finding exploits the fact that oligonucleotide distributions in the coding regions are different from those for the noncoding regions.

aTrue

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b False

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ceither true and false

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dnone of these

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View Answer

True

Which of the following is a wrong statement regarding Gene Prediction Using Markov Models and Hidden Markov Models?

aMarkov models and HMMs can be very helpful in providing finer statistical description of a gene

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bA Markov model describes the probability of the distribution of nucleotides in a DNA sequence

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cIn a Markov model the conditional probability of a particular sequence position depends on k alternate positions

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dA zero-order Markov model assumes each base occurs independently with a given probability

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View Answer

In a Markov model the conditional probability of a particular sequence position depends on k alternate positions

The conventional determination of open reading methods identify only typical genes and tend to miss atypical genes in which the rule of codon bias is not strictly followed.

a True

✓

bFalse

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ceither true and false

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dnone of these

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View Answer

True

Which of the following is a wrong statement regarding TESTCODE method?

aThis is based on the nucleotide composition of the third position of a codon

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b In practice, because genes can be in any of the six frames, the statistical patterns are computed for all possible frames

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c It is implemented in the commercial GCG package

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d It exploits the fact that the third codon nucleotides in a coding region fails to repeat themselves

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View Answer

It exploits the fact that the third codon nucleotides in a coding region fails to repeat themselves

The putative ORF can be translated into a protein sequence, which is then used to search against a protein database.

aTrue

✓

bFalse

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ceither true and false

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dnone of these

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View Answer

True

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