Bioinformatics Mcqs

Page No. 64

Which of the following is wrong statement about the maximum likelihood method’s steps?


aIt starts with an evolutionary model of sequence change that provides estimates of rates of substitution of one base for another


bIn the beginning there is an evolutionary model of sequence change that provides estimates of transitions and transversions in a set of nucleic acid sequences


cThe rates of all possible substitutions are chosen so that the base composition differs


d The set of sequences is then aligned



Which of the following is wrong statement about DNAML and DNAMLK?


aPHYLIP includes mentioned two programs for this maximum likelihood analysis


bDNAML estimates phylogenies from nucleotide sequences by the maximum likelihood method


c DNAMLK estimates phylogenies in the same manner as DNAML


d DNAMLK estimates phylogenies without molecular clock



Maximum likelihood has also been used for an analysis of mutations in overlapping reading frames in viruses.


a True


bFalse


ceither true and false


dnoe o fthese


View Answer True

The main disadvantage of maximum likelihood methods is that they are _____


amathematically less folded


bmathematically less complex


ccomputationally lucid


dcomputationally intense



The maximum likelihood method can be used to explore relationships among more diverse sequences, conditions that are not well handled by maximum parsimony methods.


a True


bFalse


ceither true and false


dnone of these


View Answer True

2. In about the maximum likelihood approach, for each tree, the number of sequence changes or mutations that may have occurred to give the sequence variation is considered.


a True


bFalse


ceither true and false


dnone of these


View Answer True

Which of the following is wrong statement about the maximum likelihood approach?


a This method doesn’t always involve probability calculations


bIt finds a tree that best accounts for the variation in a set of sequences


c The method is similar to the maximum parsimony method


dThe analysis is performed on each column of a multiple sequence alignment



Tracking the evolutionary history of individual genes in a group of species can reveal which genes have remained in a genome for a long time and which genes have been horizontally transferred between species.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

Two more recent uses of phylogenetic analysis are to analyze ______ and to trace the evolutionary history of specific genes. Which of the following could not be the correct blank?


a gene families


bgenomes


cproteomes


dphysical separation methods



The traditional use of phylogenetic analysis is to discover evolutionary relationships among species.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

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