Bioinformatics Mcqs

Page No. 64

Which of the following is wrong statement about the maximum likelihood method’s steps?


aIt starts with an evolutionary model of sequence change that provides estimates of rates of substitution of one base for another

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bIn the beginning there is an evolutionary model of sequence change that provides estimates of transitions and transversions in a set of nucleic acid sequences

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cThe rates of all possible substitutions are chosen so that the base composition differs

✓


d The set of sequences is then aligned

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Which of the following is wrong statement about DNAML and DNAMLK?


aPHYLIP includes mentioned two programs for this maximum likelihood analysis

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bDNAML estimates phylogenies from nucleotide sequences by the maximum likelihood method

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c DNAMLK estimates phylogenies in the same manner as DNAML

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d DNAMLK estimates phylogenies without molecular clock

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Maximum likelihood has also been used for an analysis of mutations in overlapping reading frames in viruses.


a True

✓


bFalse

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ceither true and false

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dnoe o fthese

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View Answer True

The main disadvantage of maximum likelihood methods is that they are _____


amathematically less folded

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bmathematically less complex

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ccomputationally lucid

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dcomputationally intense

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The maximum likelihood method can be used to explore relationships among more diverse sequences, conditions that are not well handled by maximum parsimony methods.


a True

✓


bFalse

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ceither true and false

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dnone of these

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View Answer True

2. In about the maximum likelihood approach, for each tree, the number of sequence changes or mutations that may have occurred to give the sequence variation is considered.


a True

✓


bFalse

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ceither true and false

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dnone of these

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View Answer True

Which of the following is wrong statement about the maximum likelihood approach?


a This method doesn’t always involve probability calculations

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bIt finds a tree that best accounts for the variation in a set of sequences

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c The method is similar to the maximum parsimony method

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dThe analysis is performed on each column of a multiple sequence alignment

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Tracking the evolutionary history of individual genes in a group of species can reveal which genes have remained in a genome for a long time and which genes have been horizontally transferred between species.


aTrue

✓


bFalse

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ceither true and false

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dnone of these

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View Answer True

Two more recent uses of phylogenetic analysis are to analyze ______ and to trace the evolutionary history of specific genes. Which of the following could not be the correct blank?


a gene families

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bgenomes

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cproteomes

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dphysical separation methods

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The traditional use of phylogenetic analysis is to discover evolutionary relationships among species.


aTrue

✓


bFalse

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ceither true and false

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dnone of these

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View Answer True

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