Bioinformatics Mcqs

Page No. 55

Chloroplast localization signals consist of two adjacent signal peptides, one for targeting the proteins to the stromaportion of the chloroplast before being cleaved and the other for targeting the remaining portion of the proteins to the thylakoids.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

Chloroplast localization signals are also located in the __________ terminus and are about 25 to 100 residues in length, containing very few _______ charged residues but many hydroxylated residues such as serine.


aN, negatively


b C, negatively


cC, positively


d N, positively


View Answer N, negatively

The signal sequences are typically _______ residues long, rich in _____ charged residues such as arginines as well as hydroxyl residues such as serines and threonines, but devoid of ______ charged residues.


a 28 to 80, positively, negatively


b 300 to 800, negatively, positively


c 28 to 80, negatively, positively


d300 to 500, positively, negatively



The signal sequences have a _________ consensus but contain some specific features. They all have a ______ core region preceded by one or more positively charged residues.


a weak, hydrophilic


b weak, hydrophobic


cstrong, hydrophilic


d strong, hydrophilic


View Answer weak, hydrophobic

Once the proteins are translocated within the organelles, protease cleavage takes place to remove the signal sequences and generate mature proteins.


a True


bFalse


ceither true and false


dnone of these


View Answer True

For many eukaryotic proteins, newly synthesized protein precursors have to be transported to specific membrane-bound compartments and be proteolytically processed to become functional.


aTrue


bFalse


ceither true and false


dnone of these


View Answer True

Which of the following is an incorrect statement about the terminologies related to protein sorting?


aSubcellular localization is an integral part of protein functionality


bMany proteins exhibit functions only after being transported to certain compartments of the cell


c All the proteins exhibit functions after being transported to certain compartments of the cell


dProtein sorting is also known as protein targeting



Which of the following is untrue regarding the STRING?


aSearch Tool for the Retrieval of Interacting Genes/Proteins


b Functional associations include only the direct protein-protein interactions


c It is based on combined evidence of gene linkage, gene fusion and phylogenetic profiles


dIt is a web server that predicts gene and protein functional associations



Which of the following is untrue regarding the predicting Interactions Based on Phylogenetic Information?


a Proteins do not operate as a complex


bThis method detects the co-presence or co-absence of orthologs across a number of genomes


cProtein interactions can be predicted using phylogenetic profiles


d Phylogenetic profile are defined as patterns of gene pairs that are concurrently present or absent across genomes



In Predicting Interactions Based on Gene Neighbors if a certain gene linkage is found to be indeed conserved across divergent genomes, it can be used as a strong indicator of formation of an operon that encodes proteins that are functionally and even physically coupled.


a True


bFalse


ceither true and false


dnone of these


View Answer True

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