Bioinformatics Mcqs

Page No. 45

Which of the following is untrue regarding RNA structure?


aRNA structure 4.6 is a Windows implementation of the Zuker algorithm

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bIt includes additional options for other folding algorithms and incorporation of experimental data

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cThe authors of RNA structure collaborate very closely with the Turner laboratory and keep the most up-to-date thermodynamic parameters

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dThe OligoWalk program cannot be used for siRNA design

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The probability model mentioned above was a hybrid combination of HMMs and SCFGs trained on sno RNAs.


aTrue

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bFalse

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ceither true and false

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dnone of the mentioned

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View Answer True

The probabilistic model was used to identify small nucleolar (sno) RNAs in the yeast genome that methylate ribosomal RNA.


aTrue

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bFalse

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ceither true and false

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dnone of the mentioned

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View Answer True

Fichant and Burks (1991) described a program, tRNAscan, that searches a genomic sequence with a sliding window searching simultaneously for matches to a set of invariant bases and conserved self-complementary regions in tRNAs with an accuracy of 97.5%.


aTrue

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bFalse

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ceither true and false

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dnone of the mentioned

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View Answer True

One of the first methods used to find tRNA genes was to search for sequences that are complementary and can fold into a knot like the three found in tRNAs.


aTrue

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bFalse

✓


ceither true and false

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dnone of the mentioned

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View Answer False

_____ molecules can simply be identified based on their sequence similarity with already-known sequences.


aLarger, less conserved

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bLarger, highly conserved

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csmaller, highly conserved

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dshorter, highly conserved

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One of the fundamental events that occur in meiosis is crossing over in which homologous chromosomes exchange segments causing a reshuffling of genes.


aTrue

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bFalse

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ceither ture and false

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dnone of the mentioned

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View Answer True

In medical applications, the ultimate goal of gene mapping is to disease genes.


aTrue

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bFalse

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ceither true and false

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dnone of the mentioned

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View Answer True

Cytologic maps can be considered to be of _____ resolution and hence somewhat ______ physical maps.


avery high, inaccurate

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bvery low, accurate

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cvery high, accurate

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dvery low, inaccurate

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View Answer very low, inaccurate

Which of the following is untrue about cytologic maps?


aThey cannot be directly observed under microscope

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bThey refer to banding patterns

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cThey can be viewed on stained chromosomes

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dThey can be directly observed under microscope

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