Bioinformatics Mcqs

Page No. 41

In comparative approach to RNA structure prediction, algorithms that do not use pre-alignment, align multiple input sequences and infers a consensus structure.


aTrue

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bFalse

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ceither true and false

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dnone of these

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View Answer True

Based on recent benchmark comparisons, the comparative-type algorithms can reach an accuracy range of 20% to 80%.


a True

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b False

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ceither true and false

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dnone of these

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View Answer True

The pre-alignment independent programs fare __________ for predicting long sequences.


aslight better

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bmuch better

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c a bit worse

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dmuch worse

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View Answer much worse

For _________ RNA sequences, such as tRNA, some programs may be able to produce _________% accuracy.


asmall, 70

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b small, 40

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clarge, 90

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dlarge, 75

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View Answer small, 70

If prediction accuracy can be represented using a ______ the ______ programs score roughly 20% to 60% depending on the length of the sequences.


amultiple parameter, ab initio–based

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bsingle parameter, ab initio–based

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cmultiple parameter, comparative–based

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dsingle parameter, comparative–based

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Rigorously evaluating the performance of RNA prediction programs has traditionally been hindered by the dearth of three-dimensional structural information for RNA.


aTrue

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bFalse

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ceither true and false

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dnoneof these

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View Answer True

Nussinov and Jacobson (1980) were the first to design a precise and efficient algorithm for predicting secondary structure.


a True

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bFalse

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ceither true and false

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dnone od these

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View Answer True

In 1971, first estimation of the energy associated with regions of secondary structure by extrapolation from studies with small molecules was done and then an attempt was made to predict which configurations of larger molecules were the most energetically stable.


a True

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bFalse

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ceither true and false

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dnone of these

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View Answer True

Martinez (1984) made a list of possible double-stranded regions, and these regions were then given weights in proportion to their equilibrium constants, calculated by ______


a the Boltzmann function [exp (-∆G/RT2)]

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bthe Boltzmann function [exp (-∆G/RT)]

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c the Boltzmann function [exp (-∆G/RT -T)]

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d the Boltzmann function [exp (∆G/RT)]

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The third assumption in predicting RNA secondary structure is that the structure is assumed to be formed by _____ of the chain back on itself in a manner that ________


acrossing, produces knots

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bcrossing, does not produce any knots

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cfolding, produces knots

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dfolding, does not produce any knots

✓



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