Bioinformatics Mcqs

Page No. 26

The use of low-complexity masking in the BLAST procedure means that it may have higher specificity than FASTA because potential false positives are reduced.


aTrue

✓


bFalse

✖


ceither true and false

✖


dnone of the mentioned

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View Answer True

Which of the following is not a benefit or a factual of FASTA over BLAST?


aFASTA scans smaller window sizes

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bIt gives more sensitive results

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cIt gives less sensitive results

✓


d It gives results with a better coverage rate for homologs

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BLAST uses a _______ to find matching words, whereas FASTA identifies identical matching words using the _____


asubstitution matrix, hashing procedure

✓


bsubstitution matrix, blocks

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c hashing procedure, substitution matrix

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dktups, substitution matrix

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In FASTA, For a Z-score > 15, the match can be considered extremely ______ with _____ of a homologous relationship.


ainsignificant, uncertainty

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bsignificant, uncertainty

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csignificant, certainty

✓


dinsignificant, certainty

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The function of the scoring matrix is to conduct one-to-one comparisons between all components in two sequences and record the optimal alignment results.


aTrue

✓


bFalse

✖


ceither true and false

✖


dnone of the mentioned

✖


View Answer True

Score can be negative in Smith–Waterman algorithm.


aTrue

✖


bFalse

✓


ceither true and false

✖


dnone of the mentioned

✖


View Answer False

One of the challenges in SWA is obtaining correct alignments in regions of low similarity between distantly related biological sequences.


aTrue

✓


bFalse

✖


ceither true and false

✖


dnone of the mentioned

✖


View Answer True

In SW algorithm, to align two sequences of lengths of m and n _________ time is required.


aO(mn)

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bO(m2n)

✓


cO(m2n3)

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dO(mn2)

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View Answer O(m2n)

Local sequence alignments are necessary for many cases out of which one is repeated.


aTrue

✓


bFalse

✖


ceither true and false

✖


dnone of the mentioned

✖


View Answer True

In Smith–Waterman algorithm, in initialization Step, the _________ row and ________ column are subject to gap penalty.


afirst, first

✓


bfirst, second

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csecond, First

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dfirst, last

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View Answer first, first

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