Bioinformatics Mcqs

Page No. 22

If the data set is _______ then unless the motif has __________ amino acids in each column, the column frequencies in the motif may not be highly representative of all other occurrences of the motif.


asmall, distinct

✖


bsmall, almost identical

✓


clarge, almost identical

✖


d large, distinct

✖


View Answer small, almost identical

If a good sampling of sequences is _______ the number of sequences is _________ and the motif structure is ________ it should, in principle, be possible to obtain frequencies highly representative of the same motif in other sequences also.


a available, sufficiently large, not too complex

✓


bunavailable, sufficiently large, not too complex

✖


cunavailable, sufficiently small, not too complex

✖


davailable, sufficiently large, too complex

✖


View Answer available, sufficiently large, not too complex

Two considerations arise in trying to tune the PSSM so that it adequately represents the training sequences. Which of the following is not their description?


aIf a given column in 20 sequences has only isoleucine, it is not very likely that different amino acid will be found in other sequences with that motif because the residue is probably important for function

✖


bIf a given column in 20 sequences has only isoleucine, it is very likely that different amino acid will be found in other sequences with that motif because the residue is probably important for function

✓


cIf the number of sequences with the found motif is large and reasonably diverse, the sequences represent a good statistical sampling of all sequences that are ever likely to be found with that same motif

✖


dAnother column in the motif from the 20 sequences may have several amino acids, and some amino acids may not be represented at all

✖


View Answer If a given column in 20 sequences has only isoleucine, it is very likely that different amino acid will be found in other sequences with that motif because the residue is probably important for function

The quality and quantity of information provided by the PSSM also varies for ________ in the motif.


aeach row

✖


beach column

✓


crows and columns

✖


dneither the rows nor the columns

✖


View Answer each column

Analysis of s for conserved blocks of sequence leads to production of the position-specific scoring matrix.


aTrue

✓


bFalse

✖


ceither true and false

✖


dnone of the mentioned

✖


View Answer True

Which of the following is incorrect the ‘word’ method?


aBoth BLAST and FASTA use a heuristic word method

✖


bWord method is used for fast pairwise sequence alignment in BLAST and FASTA

✖


cThe basic assumption is that two related sequences must have at least one word in common

✖


dTwo related sequences must have at zero word in common while assuming

✓


View Answer Two related sequences must have at zero word in common while assuming

Currently, there are two major heuristic algorithms for performing database searches: BLAST and FASTA.


aTrue

✓


bFalse

✖


ceither true and false

✖


dnone of the mentioned

✖


View Answer True

An increase in sensitivity is associated with _______ in selectivity.


ano specific change

✖


bincrease

✖


cdecrease

✓


dexponential increase

✖


View Answer decrease

In heuristic methods, speed doesn’t vary with the size of database.


aTrue

✖


bFalse

✓


ceither true and false

✖


dnone of the mentioned

✖


View Answer False

The specificity refers to the ability to include incorrect hits.


aTrue

✖


bFalse

✓


ceither true and false

✖


dnone of the mentioned

✖


View Answer False

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